Importantly Competent RhI-Catalyzed Asymmetric Hydrogenation of [beta]-Amino Acrylonitriles <<>>
Written by Miaofeng Ma, Guohua Hou, Tian Sun, Xiaowei Zhang, Wei Li, Junru Wang, Xumu Zhang on March 31, 2010 – 12:09 pm -It takes two to TangPhos: [beta]-Amino acrylonitriles can be willingly processed from acetonitriles. Both of the E/Z isomers undergo hydrogenation with choice enantioselectivity by using the Rh-TangPhos (TangPhos=1,1[prime]-di-tert-butyl-(2,2[prime])-diphospholane) catalyst system. The products, chiral [beta]-amino nitriles, are valuable chiral edifice blocks for multifarious drugs <<>>
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