Catalytic Asymmetric 1,3-Dipolar Cycloaddition of [alpha]-Iminonitriles <<>>
Written by Rocío Robles-Machín, Inés Alonso, Javier Adrio, Juan C. Carretero on March 31, 2010 – 12:09 pm -Improving the structural scope: A catalytic asymmetric 1,3-dipolar cycloaddition involving [alpha]-iminonitriles as azomethine precursors has been developed. In the imperturbability of AgOAc/Taniaphos as catalyst technique the counteraction of [alpha]-iminonitriles with dimethyl fumarate and N-methyl maleimide affords 2-cyanopyrrolidines with all right endo selectivity and enantioselectivity (68-[ge]99 % ee) <<>>
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