Lay out and Compounding of (13S)-Methyl-Substituted Arachidonic Acid Analogues: Templates for Novel Endocannabinoids <<>>
Written by Demetris P. Papahatjis, Victoria R. Nahmias, Spyros P. Nikas, Marion Schimpgen, Alexandros Makriyannis on February 24, 2010 – 12:16 pm -Two novel methyl-substituted arachidonic acid derivatives were instant in an enantioselective manner from commercially available chiral structure blocks, and were set to be excellent templates for the increment of (13S)-methyl-substituted anandamide analogues. One of the compounds synthesized, namely, (13S,5Z,8Z,11Z,14Z)-13-methyl-eicosa-5,8,11,14-tetraenoic acid N-(2-hydroxyethyl)amide, is an endocannabinoid analogue with remarkably loaded closeness for the CB1 cannabinoid receptor <<>>
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