Asymmetric Synthesis of 4-Amino-4H-Chromenes by Organocatalytic Oxa-Michael/Aza-Baylis-Hillman Tandem Reactions
Written by José Alemán, Alberto Núñez, Leyre Marzo, Vanesa Marcos, Cuauhtémoc Alvarado, José Luis García Ruano on July 26, 2010 – 10:06 am -Quick off the mark! In this work we present the first highly enatioselective oxa-Michael/aza-Baylis-Hillman tandem reaction between 2-alkynals and salicyl N-tosylimine leading to optically active 4-amino-4H-chromenes. This reaction takes place in less than 2 h with high yields and excellent enantioselectivities.
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